- 첨부된 파일이 없습니다.
- Hit 128
- Writer 이태화
Cellular Extensions Transport Vesicles of Scabrous that Controls Ommatidial Rotation in the Drosophila Compoun Eye (Developmental Cell, in press)
- Date/Time : Wed October 16., 2002
- Speaker : Dr. Cheng-Ting Chien
- Associate Research Fellow
Institute of Molecular Biology
- Place : Life Science Bldg. #104
- For inquires : Professor Sung Key Jang Dept. of Life Science
생명과학과 장승기 교수 (☎279-2298)
Establishment of planar polarity in the Drosophila compound eye requires precise 90o rotation of the ommatidial clusters during development. We found that the morphogenetic furrow controls the stop of ommatidial rotation at 90 by emitting signals to posterior ommatidial clusters. One such signal, Scabrous, is synthesized in the furrow cells and transported in vesicles to ommatidial row 6~8. Scabrous vesicles are transported through novel actin-based cellular extensions, but not transcytosis. Scabrous functions non-autonomously to control the stop of ommatidial rotation by suppressing nemo activity in the second 45 rotation. We propose that the morphogenetic furrow regulates precise ommatidial rotation by transporting Scabrous and perhaps other factors through actin-based cellular extensions.