Developmental and genomic evolution of vertebrate Hox genes

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  • Hit 105
  • Writer 이태화
  • 2014-01-15



Developmental and genomic evolution of vertebrate Hox genes



- 일 시 : 2001년 9월 26일(수) 16:00-17:00


- 장 소 : 생명동 104호 세미나실


- 연 사 : 김창배 박사

          (한국생명공학연구원 유전자원센터)


- Abstract

Recent development of powerful genome technologies capable of producing sequence data in large quantities is empowered mainly by Human Genome Project. The application of genomic methods to evolutionary biology is a challenge. This approach will increase species sampling levels for targeted genomes and genome regions, and sequence diversity to a certain extent to improve the quality and accuracy of phylogenetic inference for comparative studies. In the other hand, the application of conceptual and analytical tools used in phylogenetic systematics to comparative genomics is another challenge. Genome structure and function analyses can be strengthened through examining evolutionary history. The natural partnership between the co-evolving disciplines of phylogenetics and genomics is now emerging. In this study, I show how two separate principles make possible new ways of comparative analyses of vertebrate Hox clusters as an example for the new trend. This analysis aims to examine relations of different Hox genomes in vertebrates and identify regulatory regions of Hox genes. This approach will improve the understanding how the architecture of development contributes to evolvability with accurate estimates of changes in evolutionary patterns and in selective constraints. In addition this will contribute to understand the relations between Hox gene duplication and body plan complexity.

The central problem of evolutionary developmental biology (EvoDevo), a new synthesis of developmental and evolutionary biology, is to understand how the architecture of development contributes to evolvability. In this emerging synthesis, the modular organization of living systems plays a key role. Spatial and temporal expression of developmental genes depends on various cis-regulatory modules, each composed of several protein binding sites. There is accumulating evidence for cases where evolutionary changes in regulation were involved in generating major evolutionary innovations and transitions. Specific changes in particular enhancer elements of the Hoxc8 gene in some vertebrates have been reported. Assaying the respective enhancer in transgenic mouse embryos reveals that they lead to specific changes in the expression pattern of the gene, which are in accord with changes in axial morphology in the respective species. Evidence is accumulating for the involvement of regulatory  evolution in morphological changes between closely related species, as well as in major changes of body plans. The use of crosses between closely related species to map genes involved in specific alterations of morphology has been increasingly successful. The approach of testing regulatory regions from one species in another has also proven very successful. Finally, the conceptual and mathematical advances will allow us to understand full range of genotype-phenotype relations during evolution and underlying constraint operating at different levels.

- 문의처 : 한진관 교수 (279-2126)