Role of chitinase-like protein in the pathogenesis of COPD and a...

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  • Writer 이태화
  • 2014-01-22



제목: Role of chitinase-like protein in the pathogenesis of COPD and acute lung injury


연사: 이춘근 박사 (Yale University)


장소: 생명공학연구센터 1층 대강당


일시: 11월23일(월)오후5시



Recent studies from our laboratory demonstrated that chitinase-like protein proteins such as breast regression protein 39 (BRP-39) or YKL-40 (human homolog of BRP-39) may play an important role in the development of COPD. In the animal model of cigarette-smoke(CS)-induced emphysema, the null mutation of BRP-39 significantly enhanced emphysematous alveolar destruction. In humans, smokers with COPD showed exaggerated expression of YKL-40 both in the lungs and serum. Further mechanistic studies revealed that the numbers of apoptotic cells were significantly increased in the lungs of BRP-39 null mice compared to wild type controls. These studies demonstrate that BRP-39, a chitinase-like protein, plays an important role in CS-induced tissue injury response.  In this talk, I will overview evolving concepts of COPD pathogenesis and share our recent data demonstrating novel regulatory role of BRP-39 in the development of COPD and acute hyperoxygen-induced lung injury.


*문의처: 김윤근 교수(T.279-2125)