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- Hit 127
- Writer 이태화
Zebrafish as a Tool for Functional Genomics
- 일 시 : 2001년 9월 14일(금) 16:00-17:00
- 장 소 : 생명동 104호 세미나실
- 연 사 : 김철희 교수 (충남대학교 생물학과)
The vertebrate organizer can induce a complete body axis
when transplanted to the ventral side of a host embryo by
virtue of its distinct head and trunk inducing properties.
Wingless/Wnt antagonists secreted by the organizer have
been identified as head inducers. Their ectopic expression
can promote head formation, whereas ectopic activation of
Wnt signalling during early gastrulation blocks head formation.
These observations suggest that the ability of head inducers
to inhibit Wnt signalling during formation of anterior structures
is what distinguishes them from trunk inducers that permit the
operation of posteriorizing Wnt signals. Here we describe the
zebrafish headless (hdl) mutant and show that its severe head
defects are due to a mutation in T-cell factor-3 (Tcf3), a member
of the Tcf/Lef family. Loss of Tcf3 function in the hdl mutant reveals
that hdl represses Wnt target genes. We provide genetic evidence
that a component of the Wnt signalling pathway is essential in
vertebrate head formation and patterning.
- 문의처 : 한진관 교수 (279-2126)