- 첨부된 파일이 없습니다.
- Hit 154
- Writer 이태화
Elevated O-GlcNAc dependent signalling induces Apoptosis
- Date/Time : Thu October 2., 2003
- Speaker : 신상훈 박사
- National Institute of Diabetes and Digestive
and Kidney Diseases
- Place : Life Science Bldg. #104
- For inquires : Professor Sung Key Jang Dept. of Life Science
생명과학과 장승기 교수 (☎279-2298)
- Abstract -
O-linked N-acetylglucosamine transferase (OGT) catalyzes glycan addition to components of transcription and nuclear complexes and plays a role in cellular signaling. We constructed a fully functional ecdysone-inducible GFP-OGT. Elevated GFP-OGT expression induced a dramatic increase in intracellular O-GlcNAcylated proteins. Furthermore, enhanced OGT expression efficiently triggered programmed ce`ll death. Apoptosis was dependent upon OGT catalytic activity and occurred in every cell type tested including INS-1, an insulin-secreting cell line. These studies suggest that elevated flux through this glycan-dependent signaling pathway may play a role in triggering the programmed cell death observed with diseases such as diabetes and neurodegeneration.