Chemical genetics and chemical genomics: high throughput discove

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  • Writer 이태화
  • 2014-01-15



Chemical genetics and chemical genomics: high throughput discovery of drugs and disease therapeutic genes


-Date/Time : Fri November 1., 2002

          PM 2-4

- Speaker : 태국 교수

            - KAIST 생물과학과

- Place : Chemistry Bldg. #401

- For inquires : Professor Sung Ho Ryu Dept. of Life Science

           생명과학과 류성호 교수 (☎279-2292)


With advances in determining the entire DNA sequence of the human genome, it is now critical to identify and catalog genes/ proteins for specific cellular pathways (Functional Genomics/ Proteomics) and ultimately to formulate and modulate complex biological systems/ networks (Bio-Systemics).  My efforts have focused on the development of a “chemical genetic” approach that uses small molecules to probe the function of specific pathways and genes/ proteins in human cells.  Chemical genetics involves: (1) identifying small molecules that affect specific cellular pathways with unbiased phenotype-based screens; (2) characterizing their action mechanisms and identifying the proteins whose activity is affected by these chemical ligands; and (3) studying the biological consequences of inhibition or activation of the target protein using the small molecules as a tool.  These procedures yield information that is similar to what could be learned from cloning a mutant gene from a genetic screen and using a conditional allele to study the function of the protein that it encodes.  Chemical genetic approach has been complemented by various functional genomic/ proteomic approaches, which will provide the relevant and creative direction for high throughput discovery of drugs and disease genes in the “chemical genomic/medicinal genomic” approaches.  These novel approaches have been applied to the elucidation of regulation mechanisms of cell aging and immortalization, and the identification of ways to directly control these events with small molecules.