Mucosal Immune System - from food allergy to vaccine development

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  • 2014-01-17



Mucosal Immune System - from food allergy to vaccine development -


- Date/Time : Wed July 30., 2003


- Speaker : Mi-Na Kweon, Ph. D.

           - Mucosal Immunology Section International Vaccine Institute


- Place : Life Science Bldg. #104

- For inquires : Professor Young-Chul Sung Dept. of Life Science

           생명과학과 성영철 교수 (☎279-2294)


Abstract -

   The gastrointestinal immune system is a major component of the mucosal barrier which serves as a first line of defense against foreign antigens, whether microbial or dietary. A dynamic, organized and diffused lymphoid tissue network which includes Peyer's patches, crypt patches, isolated lymphoid follicles, colonic patches, lamina propria, and epithelium compartments, it normally functions to preserve the appropriate immunological homeostasis between the host and foreign antigens.  However,under certain pathological circumstances created by disturbance of the immunological balance, gastrointestinal immune system may respond abnormally to food protein antigens and so trigger allergic responses in the gastrointestinal tract. Though key to understanding gastrointestinal allergies, the workings of the mucosal immune system at the cellular and molecular level in the gastrointestinal tract have been surprisingly little studied. Though findings of interest in this field are limited by the relatively small number of experimental animal models available, I will summarize those available in order to show how they provide insight into the induction and regulation of gastrointestinal allergies and how they may lead to the development of a new mucosal immune therapy for the control of food allergies.