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[BK21 Plus Seminar]
▶Subject: Characterization of the regulatory mechanism and the pathophysiological role of Golgi outposts in neurons
▶Speaker: Prof. Sung Bae Lee (Department of Brain & Cognitive Sciences, DGIST)
▶Date: 4:30PM/Dec. 11(Wed.)/2019
▶Place: Conference room(#476), Postech Biotech Center
Neurons have extensive dendrite arbors through which connections are established between cells. Formation of these extensive dendrites require enormous amount of plasma membrane (PM) supplied by Golgi apparatus (Pfenninger, Nat Rev Neurosci 2009). In a typical cell, perinuclear Golgi easily provides PM to surrounding areas. However, in neurons, a huge burden is laid on perinuclear Golgi to supply PM to the distal areas of dendrites. To lift such burden imposed on perinuclear Golgi, neurons employ dendritic satellite secretory organelles, Golgi outposts (GOPs), through which PM is supplied locally (Ye et al., Cell 2007). These GOPs, which are present in dendrites, can quickly respond locally to signals that require the functions of Golgi, such as secretion and regulation of protein expression onto PM (Valenzuela & Perez, Front Neurosci. 2015). These GOPs are also known to nucleate microtubules (Ori-McKenney et al., Neuron 2012), thereby regulating dynamic growth and retraction of dendrites. GOPs are hypothesized to be originated from fission and dispersion of perinuclear Golgi. This hypothesis is based on the fact that in mitotic cells, perinuclear Golgi fragment and disperse into each of the dividing cell, thereby allocating Golgi to places where they are needed (Altan-Bonnet et al., Curr Opin Cell Biol. 2004). In support of this hypothesis, a recent study showed that a fission of perinuclear Golgi through the RhoA-Rock pathway led to the formation of GOPs in rat hippocampal neurons (Quassollo et al., Curr Biol 2015). Nevertheless, our understanding of the mechanism by which GOPs are formed and how their functions are regulated remain mostly undefined. In this talk, I will present our ongoing works investigating the regulatory mechanism and the pathophysiological role of GOPs in neurons.
▶Inquiry: Prof. Seung Yeol Park (279-2325)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *