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[2019 Fall Life Sciences & IBB Seminar]
▶Subject: Functional Analysis of Novel Regulators of Hippo and Wntsignaling
▶Speaker: Prof. Eek-hoonJho (University of Seoul)
▶Date: 4:30PM/Oct. 25(Fri.)/2019
▶Place: Auditorium(1F), Postech Biotech Center
Hippo signaling controls organ size by regulating cell proliferation and apoptosis. YAP is a key downstream effector of Hippo signaling and its nuclear localization is essential for the activation of target gene expression. However, the mechanism for the nuclear localization of YAP, which does not have nuclear localization signal, is unknown. Data which show that MAML1 is essential for the nuclear localization and transcriptional activation of YAP will be presented.
It is well known that β-catenin is a key mediator of Wntsignaling for the regulation of target gene expression. However, we found that transcription factor EB (TFEB) is required for the expression of about 35% of genes that are increased by the treatment of Wnt3a. TFEB is a well-known master regulator of lysosomal biogenesis and autophagy. Under nutrient deprivation condition, TFEB migrates into nucleus and stimulate expression of lysosomal genes. We found that the target genes whose expressions are regulated by Wnt/TFEB are different from the genes that are involved in lysosomal biogenesis. More data for the regulation of TFEB nuclear localization and activation of target genes will be discussed. If our data are really true, the terminology “Wnt/β-catenin signaling” should be changed to “Wnt/β-catenin-TFEB signaling”.
▶Inquiry: Prof. Seung-Yeol Park (279-2325)