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[Life Sciences Seminar]
▶Subject: Hepatitic C Virus induces changes in cellular gene expression to induce metabolic changes and immune suppression
▶Speaker: Prof. Michael Niepmann (Adjunct Professor, FachbereichMedizin,Justus-Liebig-Universität Gießen)
▶Date: 2:00 PM/Sep. 27(Fri.)/2019
▶Place: Conference room(#179), PostechBiotech Center
Hepatitis C Virus (HCV) mainly infects liver hepatocytes and replicates its single-stranded plus strand RNA genome exclusively in the cytoplasm. Viral proteins and RNA interfere with the host cell immune response, allowing the virus to continue to replicate. Therefore, in about 70 % of the cases the viral infection cannot be cleared by the immune system but a chronic infection is established, often resulting in liver fibrosis, cirrhosis and cancer (hepatocellular carcinoma, HCC). The activity of the innate immune response is suppressed by HCV using several mechanisms. We recently discovered that a long non-coding RNA (lncRNA) induces expression of GPR55 (an endocannabinoid receptor) which in turn suppresses expression of Interferon stimulated genes. Induction of cancer in the host cells can be regarded to provide further advantages for ongoing virus replication. One adaptation in cancer cells is the enhancement of cellular glucose breakdown (glycolysis) with a reduction of carbohydrate flux to the citric acid cycle and aerobic oxidative phosphorylation. This so-called aerobic glycolysis is known as the "Warburg effect" and serves to provide more anabolic metabolites upstream of the citric acid cycle like amino acids, pentoses and NADPH for cancer cell growth. HCV downregulates the expression of mitochondrial oxidative phosphorylation complex core subunits quite early after infection. In combination with enhancing the activity of the pentose phosphate pathway and reducing pyruvate dehydrogenase activity this serves to reprogramme the host cell´s metabolism to provide more metabolites for cancer cell growth. These pathways help to establish liver cancer development and chronic viral replication.
▶Inquiry: Prof. Sung Key Jang(279-2298)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *