Genetically engineered animal models: new production methods

  • Hit 402
  • Writer 최고관리자
  • 2019-06-20


[Life Sciences Seminar]


▶Subject: Genetically engineered animal models: new production methods


▶Speaker: Dr. Steve Yu (vice president, Cyagen)


▶Date: 11:00AM/Jun. 25(Tues.)/2019


▶Place: Room 104, Life Science Bldg.


While genetically engineered mouse/rat models (GEMM) have been used widely in basic biomedical research and modeling for human disease and drug development,the design and generation of these models can be complicated, time-consuming and costly. In this presentation, Dr. Steve Yu will first give an example detailing how GEMM are used in elucidating gene fuction in physiology and disease, he will then briefly reviewtraditional pronuclear injection based transgenics and ES cell homologous recombination based gene targeting, and go over the more recently developed CRISPR-mediated genome editing technology in gene targeted mouse/rat model generation, with emphasis on thepros and cons of each technology and their applications. Furthermore, he will then introduce TurboKnockout, the newest ES-cell based gene targeting technology, which allows the generation of conditional knockout/knockin and other sophisticated mouse modelsin as fast as 7-8 months, ~4-5 months shorter than the standard approach. Lastly, Dr. Steve Yu will highlight a novel online tool called Alpha knockout, which promises to revolutionize gene targeting and gene editing strategy design.


▶Inquiry: Prof. Joung-Hun Kim (279-2347)

 * This seminar will be given in English.
  Please refrain from taking photos during seminars. *