The role of extracellular vesicles in neurodegenerative diseases

  • Hit 352
  • Writer 최고관리자
  • 2018-09-19


[2018 Fall Life Sciences & IBB  Seminar]

▶Subject: The role of extracellular vesicles in neurodegenerative diseases

 ▶Speaker: Andrew F. Hill (La Trobe University)

 ▶Date: 4:30PM/Sept. 21(Fri.)/ 2018

▶Place: Auditorium(1F), Postech Biotech Center

Neurodegenerative disorders such as Alzheimer’s (AD), Parkinson’s (PD) and prion diseases are associated with proteins that misfold and deposit in the brain. Many cell types, including neurons, release extracellular vesicles (EVs) which include microvesicles and exosomes.  EVs have been shown to be involved in processing of proteins such as APP, α-synuclein, and PrP which are those involved in AD, PD and prion diseases respectively. Roles for these vesicles include  cell-cell  signalling,  removal  of  unwanted  proteins,  and  transfer  of  pathogens (including  prion-like  misfolded  proteins)  between  cells.  Our  group  has  shown  that  EV’s contain  distinct  processed  forms  of  these  proteins  and  that,  in  the  case  of  prion  disease, they  contain  the  transmissible  form  of  the  misfolded  protein.  In  addition  to  their  protein content these vesicles have recently been shown to contain genetic material in the form of protein  coding  (mRNA)  and  noncoding  RNA  species.  We  have  analysed  the  protein  and genetic cargo of EVs from a number of cell types and using deep sequencing, characterised the RNA cargo of these vesicles. As exosomes can be isolated from circulating fluids such as serum,  urine,  and  cerebrospinal  fluid  (CSF),  they provide  a potential  source  of  biomarkers for  neurological  conditions.  This  talk  will  review  the  roles  these  vesicles  play  in neurodegenerative  disease  and  highlight  their  potential  in  diagnosing  these  disorders through analysis of their RNA content.

▶Inquiry: Yong Song Gho (279-2345)

* This seminar will be given in  English.
  Please refrain from taking photos during seminars. *