DNA damage Signaling to Mitochondria in Neurodegeneration and Aging

  • Hit 520
  • Writer 최고관리자
  • 2018-06-04


[2018 Spring Life Sciences & IBB  Seminar]

▶Subject: DNA damage Signaling to Mitochondria in Neurodegeneration and Aging

▶Speaker: Prof. Vilhelm A. Bohr

▶Date: 4:30PM/Jun. 8(Fri.)/2018

▶Place: Auditorium(1F), Postech Biotech Center

We find that some DNA repair defective diseases with severe neurodegeneration have mitochondrial defects.  Our studies involve cell lines, the worm (c.elegans), and mouse models and include the conditions Xeroderma pigmentosum group A, Cockaynes syndrome and Ataxia telangiectasia.  We find a pattern of hyperparylation, deficiency in the NAD+and Sirtuin signaling and mitochondrial stress.  We are pursuing mechanistic studies of this signaling and interventions at different steps to improve mitochondrial health and neurodegeneration.  We focus on the critical role of DNA base excision repair in preventing disease and in particular on the important role of DNA polymerase β. Lack of this enzyme leads to mitochondrial dysfunction via a signaling process that is both internal and external to the mitochondria.  I will discuss recent findings that Polβ has a direct role in mitochondrial DNA repair and findings in mouse models that are deficient in this enzyme.

▶Inquiry: Prof. Seung-Jae Lee (279-2351)

* This seminar will be given in English.
Please refrain from taking photos during seminars. *