Evolution of Major Histocompatibility Complex (MHC) in Apes from

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  • 2014-01-17



Evolution of Major Histocompatibility Complex (MHC) in Apes from the View of Comparative Genomics. 


- Date/Time : Thu March 6., 2003


- Speaker :  Yoshio Tateno, Ph.D., D.Sc.

       - Center for Information Biology and DNA Data Bank of Japan

       - National Institute of Genetics

- Place : Life Science Bldg. #104

- For inquires : Professor Hong Gil Nam Dept. of Life Science

                 생명과학과 남홍길 교수 (☎279-2111)


- Abstract

  We have carried out research in evolution of the major hittocompatibility complex (MHC) genes in apes for several years in collaboration with Prof. Hidetoshi Inoko of Tokai University and his colleagues.  We are particularly interested in the origin and evolution of MHC class I genes and class I related (MIC) genes.  It is noted that because those MHC genes are functional and subject to strong natural selection, they have not evolved constantly over time.  This means that we cannot use the genes themselves to estimate their origins and evolutionary processes.  Fortunately, however, we found that many fragmentary LINEs had associated with the MHC genes in evolution.  Since the fragmentary LINEs are no longer functional and evolve constantly over time, they are suitable materials to estimate the origin and evolution of the MHC genes.  Recently, Prof. Inokos group completed sequencing a MHC region of Chimpanzee.  Using MHC genome regions of human and chimpanzee, we have estimated the origins of the MHS genes in question.