Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infecti…

  • Hit 507
  • Writer 최고관리자
  • 2018-03-26


[2018 Spring Life Sciences & IBB  Seminar]

▶Subject: Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2

▶Speaker: Prof. Ji-Hwan Ryu (Yonsei University College of Medicine)

▶Date: 4:30PM/Mar. 30(Fri.)/2018

▶Place: Auditorium(1F), Postech Biotech Center

Nod-Like Receptor family, CARD domain-containing 4 (NLRC4)-inflammasome activation is required for efficient clearance of intracellular pathogens through caspsase-1-dependent pyroptosis in macrophages. Although neutrophils play a critical role in protection from P. aeruginosa infection, the mechanisms regulating inflammasome-mediated pyroptosis in neutrophils and its physiological role are largely unknown. We sought to determine the specific mechanisms regulating neutrophil pyroptosis in P. aeruginosa strain PAO1 (PAO1) lung infection and to identify the pathological role of this process. Nox2-/- models with reduced neutrophil antibacterial activity exhibited increased neutrophil pyroptosis, which was mediated by flagellin, a pathogenic PAO1 component. We also demonstrate that PAO1-induced pyroptosis depended on NLRC4 and Toll-like receptor 5 (TLR5) in neutrophils generated from Nlrc4-/-,orTlr5-/-mice. Our study reveals previously unknown mechanisms and physiological role of neutrophil pyroptosis during P. aeruginosa lung infection. Furthermore, our findings regarding neutrophil pyroptosis in the context of neutrophil dysfunction may explain the causes of acute and/or chronic infectious diseases discovered in immune-compromised patients.

▶Inquiry: Prof. Kunyoo Shin (279-2358)

* This seminar will be given in English.
Please refrain from taking photos during seminars. *