Intrapopulation diversity in G1 length underlies pluripotency

  • Hit 665
  • Writer 최고관리자
  • 2018-02-19


[2018 Spring Life Sciences & IBB  Seminar]

▶Subject: Intrapopulation diversity in G1 length underlies pluripotency

▶Speaker: Prof. Jiwon Jang (Department of Life Sciences, POSTECH)
▶Date: 4:30PM/Feb. 23(Fri.)/2018
▶Place: Auditorium(1F), Postech Biotech Center
The link between single cell variation and population level fate choices lacks a mechanistic explanation despite the extensive observations of gene expression variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials toward either neuroectoderm or mesendoderm depending on their G1 lengths even before the onset of differentiation. Therefore, single cell variation in G1 length establishes a probability distribution that determines the fate of the population. Global 5-hydroxymethylcytosine levels are regulated by G1 length and thereby link G1 length distribution patterns to differentiation outcomes of hESC populations. Although sister stem cells generally share G1 lengths, a variable proportion of asymmetric G1 lengths can shift the G1 length probability curve. Environmental levels of WNT control the distribution curves of G1 length, and thereby determine differentiation potential of hESC populations. Our findings suggest G1 length distribution as a core mechanism linking single cell variation to population outcome.

▶Inquiry: : Prof. Kunyoo Shin (279-2358)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *