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[2014 Spring Life Sciences & IBB Regular Seminar]
▶Subject: Cereblon ? A new regulator of T cell activation
▶Speaker: Sung Gyoo Park, Ph.D. (GIST)
▶Place: Chemistry Bldg. #401
Cereblon (CRBN) is a well-known target of thalidomide, which is increasingly used as an immune modulatory drug. Thalidomide increases immune cell activation and cytokine production, including CD4+ T cell activation and IL-2 production. Here, we show that CRBN deficiency in CD4+ T cells increased IL-2 production and early activation. In addition, CRBN deficiency in na?ve CD4+ T cells dramatically increased potassium channel expression levels. Finally, CRBN was found to bind to potassium channel and regulate calcium influx through the control of potassium flux. CRBN plays a role in CD4+ T cell activation by regulating potassium channel expression levels and channel activity.
▶Inquiry: Prof.Yoontae Lee(279-2354)
* This seminar will be given in English