POSTECH 생명과학과

Faculty and research

Faculty
and research
Research highlight
리서치하이라이트

Fast and Precise: How to Measure Meiotic Crossovers in Arabidopsis

첨부파일
  • 첨부된 파일이 없습니다.
  • 저널명Mol Cells . 2022 May 31;45(5):273-283
    • 담당교수Kyuha Choi
    • 조회330
    • 작성자최고관리자
    • 2022-10-07

    본문

    ■ Abstract

    During meiosis, homologous chromosomes (homologs) pair and undergo genetic recombination via assembly and disassembly of the synaptonemal complex. Meiotic recombination is initiated by excess formation of DNA double-strand breaks (DSBs), among which a subset are repaired by reciprocal genetic exchange, called crossovers (COs). COs generate genetic variations across generations, profoundly affecting genetic diversity and breeding. At least one CO between homologs is essential for the first meiotic chromosome segregation, but generally only one and fewer than three inter-homolog COs occur in plants. CO frequency and distribution are biased along chromosomes, suppressed in centromeres, and controlled by pro-CO, anti-CO, and epigenetic factors. Accurate and high-throughput detection of COs is important for our understanding of CO formation and chromosome behavior. Here, we review advanced approaches that enable precise measurement of the location, frequency, and genomic landscapes of COs in plants, with a focus on Arabidopsis thaliana.


    2fd6da5283deb41e67438b3b4dc8cbd7_1665104993_7673.jpg


    Top