Lab. of Immune Regulation and Tolerance
Our lab is interested in understanding genetic (transcription factors) and environmental factors (gut microbiota) that shape our immune system, with the goal of developing immuno-therapies.
We screen for probiotic strains with strong immuno-suppressive or immuno-stimulatory property, and identify effector molecules plus their modes of action. We also study the biology of immune suppressing T cells (Treg), the factors that control Treg stability and function. Also, we study the transcriptional regulation of immune suppressing cytokine, IL-10. These research will be used to develop therapy to inflammatory disease (Allergy, Atopy, Autoimmune disesease) and to develop anti-cancer therapy.