Lab. of Cancer and Immune Regulation
Research areas that we are interested in include cancer and immunology. We are currently investigating roles of the transcriptional repressor Capicua (CIC) in cancer progression and lymphocyte development. Based on our findings, CIC negatively regulates pathogenesis of several different types of cancer including prostate, liver, and breast cancer, and maintains immune homeostasis through modulating activation and differentiation of lymphocytes. We will uncover CIC-mediated gene expression regulatory networks in cancer and immune cells to identify novel key players in regulation of cancer progression and immune responses. For our studies, we employ various experimental tools and skills, ranging from molecular and cellular biological approaches to in vivo mouse genetics. The main goal of our study is to provide better insights on therapeutics for cancers and immune disorders.