he ultimate goal of our research is to understand the regulatory circuitry of the host defense system against infection. In particular, our research interest lies in bio-circuitry that governs recognition and strategic cope plan against pathogen-originated molecular patterns. Metazoans have developed a sophisticated defense system according to their cellular diversity, dynamics, and system complexity. Thus it is extremely difficult to accurately characterize the regulatory modules and molecular switches that govern the cellular homeostasis against pathogenic infection. Our current & future research aim on the characterization, utilization, and engineering of signaling machinery and the transcriptional circuitry of the defense system against infection