Highly pathogenic avian H5Nx influenza breaks and investigation of the…

  • Hit 66
  • Writer 최고관리자
  • 2017-04-12


[BK21 Plus Seminar]

▶Subject: Highly pathogenic avian H5Nx influenza breaks and investigation of their pathogenic potentials

▶Speaker: Young Ki Choi, DVM, Ph.D. (College of Medicine, Chungbuk National University)
▶Date: 1:00PM/April. 14(Fri)/2017
▶Place: Life Science Bldg. #104
The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation of reassortant H5 strains with novel gene constellations.  A newly emerged highly pathogenic avian influenza (HPAI) A(H5N8) virus caused poultry outbreaks in the Republic of Korea (Korea) in mid-January 2014. Despite control measures on A(H5N8)-infected farms, the virus still managed to spread widely in Korea, resulting in the culling of more than 16 million poultry birds within a short period of time. Furthermore, the HPAI H5N8 viruses spread to Europe and Northe America, where they were detected in domestic birds, wild birds. Although the HPAI H5N8 was highly pathogenic in chickens but was less than stellar at inducing remarkable clinical illness in domestic ducks and ferrets, which may allow establishment of the virus in this host. Furthermore, the virus was moderately pathogenic in mice and had limited tissue tropism relative to that of previous HPAI H5N1 viruses. Although these findings minimize the concern that these HPAI A(H5N8) viruses in its present phenotype would cause human infections, data also indicate that the virus may have the potential to become endemic in domestic poultry, which could alter genetic evolution of pre-existing strains. In circumstance of world spread of the H5N8 virus and co-circulation with previous HPAI H5N1 viruses, studies on detailed virulence factors and pathogenic potentials of novel H5N8 or its reassortants with preexisting H5 viruses were limited. Therefore, in this study, we investigate the detailed virulence factors of HPAI H5N8 virus by comparing with recent HPAI H5N1 (A/EM/Korea/W149/2006, clade 2.2) and evaluated the pathogenic potentials of H5N8 possible reassortants to evolve to cause highly pathogenic viruses in mice model.
Keywords: avian influenza virus, HPAI A(H5N8), reassortment, migratory waterfowls, genetic evolution, virulence marker

▶Inquiry: Prof. Joo-Yeon Yoo (279-2346)
* This seminar will be given in Korean.
Please refrain from taking photos during seminars. *