Genomics and Systems/Synthetic Biology of Microbes and Microbiomes

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  • Writer 최고관리자
  • 2017-03-20


[2017 Spring Life Sciences & IBB  Seminar]

▶Subject: Genomics and Systems/Synthetic Biology of Microbes and Microbiomes

▶Speaker: Prof. Jihyun F. Kim (Department of Systems Biology, Yonsei University)
▶Date: 4:30PM/Mar. 23(Thur.)/2017
▶Place: Auditorium(1F), Postech Biotech Center
With the advent of the genomics era powered by high-speed high-throughput next-generation sequencing technologies, life science is being transformed and biological research and development have been significantly accelerated. We applied genomic and metagenomic tools to study model microbes and microbial communities. Comparative evolutionary studies of the genomes of commensal or pathogenic Escherichia coli and Shigella strains suggest lifestyle-specific gene contents and genomic configuration. Systems-level comparative multi-omics analysis of two model cell factories E. coli B and K-12 may open the door to synthetic biology and next-generation biotechnology for sustainable biofuels and biochemicals, in addition to overexpression of heterologous proteins of biomedical importance or membrane residence. Analysis of the genomes sampled through 40,000 generations from a laboratory population in a long-term evolution experiment revealed that the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. Host physiology can be fully understood only if the microbial counterparts that reside in are fully appreciated. Host-microbiota relationships in human and plant diseases will be presented as examples: profiles of microbiota associated with gastric cancer and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) for the human gastrointestinal tract and the role of microbiome in disease resistance or susceptibility of tomato varieties against bacterial wilt for the plant rhizosphere. In the talk, the marine ecosystems will also be presented: genomic research of two marine microbes, Hahella chejuensis and Donghaeana dokdonensis, and marine mesocosm experiments that investigate the influences of ocean acidification and global warming to the dynamics of marine microbial communities. Environmental genomics will be the major force in understanding the structure and function of microbial ecosystems in humans and their effects to human well-being.

▶Inquiry: Prof. Kim You-Me (279-0689)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *