POSTECH 생명과학과
Seminar
Seminar

Golgi outposts are essential to restore terminal dendrite elongation i…

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  • Writer 최고관리자
  • 2017-03-08

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[2017 Spring Life Sciences & IBB  Seminar]

▶Subject: Golgi outposts are essential to restore terminal dendrite elongation impaired by nuclear proteotoxicity

▶Speaker: Prof. Sung Bae Lee (Department of Brain & Cognitive Sciences, DGIST)
       
▶Date: 4:30PM/Mar. 10(Fri.)/2017
                   
▶Place: Auditorium(1F), Postech Biotech Center
                           
▶Abctract
For proper functioning of neurons, dynamic features of synapse formation are essential. Synaptic plasticity requires continuous, intricate remodeling of structures and properties of the distal dendrites. Therefore, imbalance in these dynamic features can cause temporal neuronal dysfunction or neurological disorders in chronic cases.
Notably, much of the symptoms associated with neurodegenerative diseases that tend to manifest themselves in the early stages evidently may primarily hold the aforementioned imbalance liable, and not the neuronal cell-death themselves. In this regard, our group is working on the harmful effect of protein toxicity closely associated with many neurodegenerative diseases on neuronal dynamics. We are using polyglutamine (polyQ) protein toxicity as a model for neuronal protein toxicity and now focusing on its noxious effect on the endomembrane dynamics in both supplying and recycling local membranes to sustain terminal dendrite structure and function. In sum, our study unveiled cellular mechanisms involved in this altered dynamics of membranes in the afflicted neurons and identified key mediators of this event from genetic study, which in turn may be useful in designing strategies for effective therapeutic agents especially targeting early neuropathy of certain diseases before massive neuronal cell death.

▶Inquiry: Prof. Il-Doo Hwang (279-2291)
 
* This seminar will be given in English.
Please refrain from taking photos during seminars. *

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