생명과학과 신임교원 채용 후보 공개세미나

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  • 2017-01-06


생명과학과 신임교원 채용 후보 공개세미나
[Life Sciences Faculty Candidate Seminar Notice]
              ▶Subject: Natural Variation in the Plant Immune System and its Adaptive Value
              ▶Speaker: Eunyoung Chae, Ph.D. (Max Planck Institute)
              ▶Date: 4:00 PM/Dec. 7(Wed.)/2016
              ▶Place: Auditorium(1F), Postech Biotech Center
 Individuals of a species respond differently to environmental perturbations and the genetic makeup is largely responsible for the variation in responses. Now is the most exciting time to investigate the phenotypic variation in complex traits governed by genotype by environment (G x E), as the advent of new sequencing tools made tremendous genomic information available in a given species [1]. Numerous genome- sequencing projects revealed that genetic variability in plant immune components is exceptional, reflecting complex defense strategies that plants employ to fend off myriad pathogens that they encounter in their life time. The extreme variation sometimes makes a fatal outcome. Hybrid necrosis is the best-known example of genetic incompatibility in plants in that autoimmune responses are triggered by deleterious interactions of independently evolved immune alleles [2]. My postdoctoral research exploited genetic and genomic tools available in the model plant species Arabidopsis thaliana to systematically investigate intraspecific hybrid necrosis, which uncovered significant contribution of the NLR-type immune receptor to autoimmunity [3]. The species-wide work identified several incompatibility hot spots in the genome, often in regions densely populated by NLR immune receptor genes with high variability in the populations. A particularly dangerous locus is a highly variable cluster of NLR genes, DANGEROUS MIX2 (DM2), which causes multiple, independent incompatibilities with genes that encode a range of biochemical functions, including other NLRs. Our findings suggest that deleterious interactions of immune components at the front lines of host-pathogen co-evolution limit the combinations of favorable disease resistance alleles accessible to plant genomes.
 This systematic work provides a unique platform to further investigate molecular mechanisms of immune receptor activation and to dissect tradeoffs between immunity and growth in plants [4]. In my job talk at POSTECH, I will address topics on how genetics of speciation and genetic incompatibility contribute to mechanistic understanding of adaptation, how natural variation can be exploited to understand trait evolution, and how current knowledge gained from a model system can be translated to solve real-world problems.