Mitochondrial Regulation of Inflammasomes Activation: it’s implication…

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  • 2017-01-06


[BK21 Plus Seminar]
                      ▶Subject: Mitochondrial Regulation of Inflammasomes Activation: it’s implication in Health & Disease
                      ▶Speaker: Min-Jong Kang, M.D., Ph.D. (Department of Internal Medicine,Yale University School of Medicine)

                    ▶Date: 4:30PM/Nov. 3(Thu.)/2016
                      ▶Place: Conference Room(#376), Postech Biotech Center
                      Inflammasomes constitute a critical component regulating inflammation, a fundamental response of the innate immune system to noxious stimuli. During infection or injury, inflammasomes are activated by a wide array of pathogen-associated molecular patterns (PAMPs) or endogenous danger-associated molecular patterns (DAMPs) and, under normal circumstances, culminates in the resolution of infection or inflammation and return to homeostasis. However, inappropriate or chronic activation of inflammasomes can lead chronic inflammation and autoimmune disease states, including those that affect lung. Recently, we observed that (i) Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasomes activation is associated with mitochondrial dysfunction in macrophages; (ii) this mitochondrial dysfunction culminates into the accumulation of mitochondrial antiviral signaling protein (MAVS), a key adaptor molecule of innate immune regulation, on mitochondria; and (iii) the Cigarette smoke (CS)-induced inflammasomes activation and the resultant CS-induced pulmonary inflammation and remodeling responses are significantly ameliorated in the absence of MAVS.  In addition, we observed that phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1), an important regulator of mitochondrial homeostasis, regulates MAVS-mediated inflammasomes activation via its dynamic interaction with MAVS during the inflammasomes activation. Here, these recent discoveries on mitochondrial biology in association with inflammasomes activation and their implications on human health and diseases are summarized. In addition, the current limitations of our understanding on this theme and future research directions are discussed.

                  ▶Inquiry: Prof. Gho, Yong Song (279-2345)
                        * This seminar will be given in Korean.
                    please refrain from taking photos during seminars. *