Fishing for the regulators of tissue regeneration

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  • 2017-01-06


[BK21 Plus Seminar]
                  ▶Subject: Fishing for the regulators of tissue regeneration
                  ▶Speaker: Junsu Kang, PH.D. (Duke University Medical Center, The Department of Cell Biology)

                  ▶Date: 4:00 PM/Oct. 4(Tue.)/2016
                  ▶Place: Life Science Bldg. #104
                    The capacity for complex tissue regeneration is unevenly distributed among vertebrate tissues and species. While mammals have limited regenerative capabilities, zebrafish possess a remarkable potential to regenerate tissues such as amputated appendages and damaged heart muscle. However, little is known about the molecular basis for the presence or absence of regenerative capacity, which likely involves changes in both cell-intrinsic and –extrinsic factors. For instance, zebrafish are capable of regenerating amputated fins throughout life, but pectoral fins display a sexually dimorphic regeneration phenotype, which is poorly understood at cellular and molecular level. I have discovered that male pectoral fins have reproductive structures, which secrete Dickkopf 1 (Dkk1), an antagonist of Wnt signaling, to aid their continual turnover. Interestingly, this inhibitory signal appears to impede the regenerative capacity of male pectoral fins after amputation, suggesting that signaling crosstalk between neighboring tissues can influence regeneration. In addition, I have identified members of a valuable class of epigenetic factors: tissue regeneration enhancer elements that are activated in regenerating tissues. Using genome-wide analysis and transgenic assays, I found that there are enhancers with regeneration-restricted activity that is linked to leptin b (lepb). The activity of the lepb-linked regeneration enhancer (LEN) can be harnessed to modulate tissue regenerative capacity. These results provide evidence for ‘Tissue Regeneration Enhancer Elements’ (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs. In this presentation, I will discuss how environmental, epigenetic, and genetic factors influence tissue regeneration in zebrafish and suggest new therapeutic strategies for tissue repair.

              ▶Inquiry: Prof. Lee, Seung-Jae(279-2351)
                    * This seminar will be given in English.
                please refrain from taking photos during seminars. *