Hedgehog signaling in stem cell, regeneration, and cancer

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  • 2016-03-04


[2016 Spring Life Sciences & IBB Regular Seminar]

▶Subject: Hedgehog signaling in stem cell, regeneration, and cancer

▶Speaker: Prof.Kunyoo Shin (POSTECH)

▶Date: 4:00PM/Mar. 4(Fri.)/2016

▶Place: Auditorium(1F), Postech Biotech Center

Our research is focused on the signaling networks that operate in stem cell regulation during tissue homeostasis and regeneration, and in cancer. We began this research with our earlier work that identified epithelial stem cells in the urinary bladder. This work focused on the identification of epithelial stem cells in the urinary bladder and on the characterization of signaling pathways that play a crucial role in the regenerative response of bladder to chemical or bacterial injury (Shin, Beachy, Nature 2011). This work laid a foundation for our subsequent study of the cell of origin for bladder cancer. The core of this work is an examination of the cell of origin of invasive bladder carcinoma using an unbiased chemical carcinogenesis model that closely mimics human carcinogenesis, addressing long-standing issues concerning the cell of origin in cancer and the natural history of cells as they progress through a pre-cancerous state in invasive carcinoma (Shin, Beachy, Nature Cell Biology 2014). Most recent work in my laboratory showed the unexpected role of Hedgehog signaling pathway activity in bladder cancer progression. In this work we showed that Shh expression is absent from human invasive bladder carcinomas, and explored in our murine chemical carcinogenesis model the consequences of this loss (Shin, Beachy, Cancer Cell 2014). In addition to bladder works, we recently examined the growth and branching morphogenesis of regenerating adult prostate with relevance to very common disease, benign prostate hyperplasia. In this work we elucidated the mechanisms underlying specification of branching location. Based on three-dimensional reconstructions from two-photon microscopy, which reveal the striking absence of Hedgehog response in stromal cells located at the sites of nascent buds in regenerating prostate tubules, we investigated the role of Hh signaling (Lim, Shin, Beachy, Nature Cell Biology 2014)

▶Inquiry: Prof. Yoontae Lee(279-2354)
* This seminar will be given in English.
please refrain from taking photos during seminars. *