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In vivo role of Id2 in cell growth and differentiation control
- Date/Time : Wed., 24 July 2002
- Speaker : Dr. Yokota Yoshifumi
- Fuki Medical University
- Place : Life Science Bldg. #104
- For inquires : Professor Young-Yun Kong Dept. of Life Science
생명과학과 공영윤 교수 (☎279-2287)
To build our bodies from a single fertilized egg, we require enormous multiplication and diversification of cells and these processes must be coordinated properly. Id proteins, negative regulators of basic helix-loop-helix (bHLH) transcription factors, are good experimental tools to investigate mechanisms underlying the regulation of cell proliferation and differentiation, because they possess the ability to inhibit differentiation and to stimulate proliferation. Four members, Id1 through Id4, have been identified in mammals. I have been working with mice lacking Id2 for the last several years. Id2-deficient mice have revealed that Id2 plays a pleiotropic role in a variety of tissues such as the immune system and reproductive organs. I would like to present our recent data and discuss in vivo roles of Id2 in cell differentiation and proliferation. Major topics are the development of cells and mammary glands.