- Hit 81
- Writer 최고관리자
[Life Sciences Seminar]
▶Subject: Histone H2A variants determine the genome architecture in Arabidopsis
▶Speaker: Chulmin Park, Ph.D. (Gregor Mendel Institute (GMI))
▶Date: 2:00PM/Oct. 14(Mon.)/2019
▶Place: Auditorium(1F), Postech Biotech Center
Eukaryotic genomes are primarily packaged by histones from the H2A, H2B, H3, H4 and H1 families into chromatin. Nucleosome is the basic unit of chromatin comprising 146 base pairs of DNA wrapped around octamers of histones (two heterodimers H2A-H2B, and tetramer formed by two H3 and two H4). Interestingly, nucleosome composition is not uniform due to substitutions of the histones with non-allelic isoforms (histone variants) and post-translational histone modifications (histone marks). To understand the genome organization of Arabidopsis, we analyzed genome-wide profiling of 8 histone variants and 8 histone marks. In addition, to cytologically investigate the spatial organization of the histone variants and histone marks, we have used a Structured Illumination Microscopy (SIM) which has ~100nm resolution. Both genome-wide profiling and cytological data indicate that the main determinant factors of genome organization of Arabidopsis are histone H2A variants. Our genome-wide profiling data and the super-resolution images of histone variants and histone marks provide a comprehensive framework for genome organization of Arabidopsis.
▶Inquiry: Prof. Kyuha Choi (279-2361)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *