A molecular link between host recognition of pathogen effectors and MA…

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  • Writer 최고관리자
  • 2018-07-10


[BK21 Plus Seminar]

▶Subject: A molecular link between host recognition of pathogen effectors and MAPK signaling

▶Speaker: Gregory B. Martin, Ph. D
                    (Section of Plant Pathology and Plant-Microbe Biology, School of Integrative Plant Science Cornell University)

▶Date: 4:30 PM/Jul. 17(Tue.)/2018

▶Place: Auditorium(1F), Postech Biotech Center

The interaction of tomato with Pseudomonas syringae pv. tomato (Pst) causes bacterial speck disease and is a model system for investigating the molecular basis of NOD-like receptor (NLR) activation and ETI-associated signaling pathways. The tomato NLR protein Prf acts with host protein kinases Pto and Fen to activate ETI. Pto and Fen bind the Pst effectors AvrPto or AvrPtoB possibly by acting as ‘decoys’ of the virulence targets of these effectors. Host responses activated by Pto/Prf include phosphorylation of mitogen-associated protein kinases (MAPKs), transcriptional reprogramming, and localized programmed cell death (PCD). Several years ago, MAPKKKa (M3Ka) was identified as a positive regulator of MAPK signaling leading to PCD, although the molecular mechanisms acting between Pto/Prf recognition of AvrPto/AvrPtoB and M3Ka were unknown. We recently identified a M3Ka-interacting protein, Mai1, that has a protein kinase domain and a tetratricopeptide repeat (TPR) domain. Virus-induced gene silencing of Mai1 in Nicotiana benthamiana compromises PCD induced by Pto/Prf and PCD was restored by expression of a synthetic Mai1 gene that resists silencing. Mai1 silencing also compromised resistance to Pst mediated by Pto/Prf. Co-expression of Mai1 with M3Ka in leaves enhances MAPK phosphorylation and accelerates PCD. These findings indicate that Mai1 acts as a molecular link between host recognition of pathogens and MAPK signaling.

▶Inquiry:  Prof. Kee  Hoon Sohn (279-2357)

* This seminar will be given in  English.
  Please refrain from taking photos during seminars. *