“Searching for memory and engram”

  • Hit 20
  • Writer 최고관리자
  • 2018-05-15


[2018 Spring Life Sciences & IBB  Seminar]

▶Subject: “Searching for memory and engram”

▶Speaker: Prof. Bong-Kiun Kaang

▶Place: Auditorium(1F), Postech Biotech Center

 Learning is the process by which we obtain the information about the world; memory is the process by which that information is stored. Long-term memory formation requires post-transcriptional as well as transcriptional regulation in the brain. We are interested in finding what molecular and cellular mechanisms underlie memory storage. To map the landscape of the translatome and transcriptome during memory formation, we have performed ribosome profiling and RNA-seq in mouse hippocampus following contextual fear conditioning. We found three major waves of gene regulation during memory formation. By offering the comprehensive translatome and transcriptome data, our study reveals previously unappreciated regulatory events underlying learning and memory. Finally, I will present our recent structural and functional approaches to reveal enhanced structural and functional connectivity between engram cells in the hippocampus during memory formation. Our data demonstrated that enhanced structural and functional connectivity between engram cells across two directly connected brain regions in the hippocampus forms the synaptic correlate for memory formation as was prophesied by Donald Hebb 70 years ago.

▶Inquiry: Prof. Joung-Hun Kim (279-2347)

*This seminar will be given in English.
*Please refrain from taking photos during seminars.