“Functional conservation but regulatory divergence of the plant SnRK1 …

  • Hit 153
  • Writer 최고관리자
  • 2018-04-05


[2018 Spring Life Sciences & IBB  Seminar]

▶Subject: Functional conservation but regulatory divergence of the plant SnRK1 energy sensor, the ortholog of mammalian AMPK

▶Speaker: Filip Rolland

▶Date: 4:30PM/Apr. 6(Fri.)/2018

▶Place: Auditorium(1F), Postech Biotech Center

The plant heterotrimeric SnRK1 (SNF1-related kinase1) ortholog of animal AMP-activated kinase (AMPK) and yeast Sucrose Non-Fermenting1 (SNF1) is highly conserved in structure and function, but regulation of the plant kinase complex appears to have evolved differently. Cellular transient expression and yeast mutant complementation assays in combination with mutant and transgenic plant analyses indicate that plant SnRK1 harbors an active regulatory subunit-independent catalytic a subunit. Diverse types of low energy stress trigger nuclear translocation of the a subunit to activate target gene expression. The regulatory b subunits act as negative regulators of SnRK1a nuclear activity, at least in part by restricting its nuclear localization. Plants with altered SnRK1a subunit localization are affected in both metabolic stress responses and shoot and root development, revealing new nuclear and cytoplasmic SnRK1 functions. Together with the recent identification of diverse other SnRK1 inhibitors, these results indicate that plants have tuned an ancient and highly conserved regulatory pathway to their preferred negative regulation strategy to better fit their autotrophic and sessile lifestyle and more efficiently cope with rapidly changing environmental conditions.

▶Inquiry: Prof. Il-Doo Hwang  (279-2291)

* This seminar will be given in English.
Please refrain from taking photos during seminars. *