Unraveling the role of MATR3 in amyotrophic lateral sclerosis (ALS)

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  • Writer 최고관리자
  • 2017-11-22


[BK21 Plus Seminar]

▶Subject: Unraveling the role of MATR3 in amyotrophic lateral sclerosis (ALS)

▶Speaker: Prof. Jeehye Park (Assistant Professor, Department of Molecular Genetics, University of Toronto)
▶Date: 4:00PM/Dec. 12(Tue.)/2017
▶Place: Auditorium(1F), Postech Biotech Center 
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is one of the most common neurodegenerative diseases characterized by progressive muscle weakness due to degeneration of motor neurons in the brain and spinal cord. There is no cure or effective treatment for this devastating disease. Many genetic mutations have been discovered in ALS patients, but we do not clearly understand how these mutations cause ALS. Interestingly, a large number of mutations are identified in genes that encode RNA binding proteins (RBPs) or those that are involved in RNA metabolism, suggesting that dysregulation in RNA homeostasis is one of the major causes that lead to motor neuron degeneration. To test our hypothesis, our lab is studying an ALS-causing RBP called Matrin-3 (MATR3). We generated mouse models with an ALS-associated mutation in Matr3 and are in the process of characterizing its pathophysiological features of ALS. We are also investigating the molecular mechanism by which MATR3 mutations cause motor neuron degeneration and determine whether dysregulation in RNA homeostasis is involved in the pathogenesis. In addition, we plan to identify pharmacologically tractable targets or pathways that ameliorate disease pathogenesis caused by mutant MATR3. Altogether, the phenotypic outcomes from the Matr3 mouse model and the functional data arises from our studies will yield clues to understanding the disease pathogenesis and help gain insight into the roles of other ALS-causing RBPs and thereby inform new therapeutic opportunities for ALS.

▶Inquiry: Prof. Yoontae Lee (279-2354)

* This seminar will be given in English.
Please refrain from taking photos during seminars. *