Blocking promiscuous activation at cryptic promoters directs cell type…

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  • Writer 최고관리자
  • 2017-11-22


[BK21 Plus Seminar]

▶Subject: Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression

▶Speaker: Jongmin Kim Ph.D. (Department of Molecular Biology, Massachusetts General Hospital)
▶Date: 11:00AM/Nov. 22(Wed.)/2017
▶Place: Life Science Bldg. #104
A single cell uses only a subset of its genome to establish and maintain its unique identity. To selectively express cell type-specific transcripts during development, it is critical to maintain genes required for other lineages in a silent state. Here, we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific zinc finger protein, Kumgang (Kmg), working with the chromatin remodeler dMi-2 prevents transcription of genes normally expressed only in somatic lineages. By blocking transcription from normally cryptic promoters, Kmg restricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male germ cell differentiation. Our results suggest that as new regions of the genome become open for transcription during terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activation.

▶Inquiry: Prof. Joo-Yeon Yoo (279-2346)

* This seminar will be given in English.
Please refrain from taking photos during seminars. *