POSTECH 생명과학과
Seminar
Seminar

Cereblon ? A new regulator of T cell activation

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  • 2014-04-14

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[2014 Spring Life Sciences & IBB Regular Seminar] 



 



 



▶Subject: Cereblon ? A new regulator of T cell activation


    


 


▶Speaker: Sung Gyoo Park, Ph.D. (GIST)


     


 


▶Date: 4:00PM/April/11(Fri)/2014


    


  


▶Place: Chemistry Bldg. #401


    


 


   *Abctract


    Cereblon (CRBN) is a well-known target of thalidomide, which is increasingly used as an immune modulatory drug. Thalidomide increases immune cell activation and cytokine production, including CD4+ T cell activation and IL-2 production. Here, we show that CRBN deficiency in CD4+ T cells increased IL-2 production and early activation. In addition, CRBN deficiency in na?ve CD4+ T cells dramatically increased potassium channel expression levels. Finally, CRBN was found to bind to potassium channel and regulate calcium influx through the control of potassium flux. CRBN plays a role in CD4+ T cell activation by regulating potassium channel expression levels and channel activity.






 


▶Inquiry: Prof.Yoontae Lee(279-2354)


   


 


 * This seminar will be given in English






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