POSTECH 생명과학과
대표연구성과
대표연구성과

RNA surveillance via nonsense-mediated mRNA decay is crucial for longe…

첨부파일
  • 첨부된 파일이 없습니다.
  • 저널명Nature Comm, Article number: 14749 (2017) doi:10.1038/ncomms14749
    • 담당교수[2017년 9월] 이승재 교수연구실
    • 조회226
    • 작성자최고관리자
    • 2017-10-17

    본문

    Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations.

    Top