Regulation of cell fate in the osteoimmune system

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  • 2013-04-09



DATE: 4:00 PM, Friday, April. 12

PLACE: Auditorium(1F), POSTECH Biotech Center

Yong Won Choi | University of Pennsylvania

Inflammation, Infection and Beyond: "RANKL and Perspective on Osteoimmunology"

Study of bone and the immune system have converged in recent years under the banner of osteoimmunology. This is particularly true for studies of the development of immune cells, which are spawned in the bone marrow reservoir. Moreover, it is now recognized that bone contains important niches that regulate the functions of memory lymphocytes. At the same time, various factors produced during immune responses are capable of profoundly effecting the regulation of bone turnover. Although mechanisms have evolved to prevent the immune system from excessively interfering with bone homeostasis, pathologic bone loss is a common sequela associated with inflammation, autoimmunity, and cancer. There are also developmental links and parallels between bone and the immune system. Cells that regulate bone turnover share a common precursor with inflammatory immune cells, and may restrict themselves anatomically, in part, using a signaling network analogous to the costimulatory signals required for lymphocyte activation. Efforts are currently underway to further characterize how these two organ systems overlap, and to develop therapeutic strategies based on these interactions. We will discuss an update on the modulatory factors influencing RANKL-induced osteoclast differentiation and also potential implication of osteoclast crosstalk to adaptive immune responses.