안지완 교수 Profile

  • 경력
  • 논문
  • 연구분야
| Education |
B.S., University of Auckland, New Zealand (1998)
M.S., University of Auckland, New Zealand (2000)
Ph.D., University of Auckland, New Zealand (2004)

| Career |
2003~2008: Postdoctoral Fellow, Department of Radiation Oncology, Stanford University School of Medicine
2008~2011: Research Associate, Department of Radiation Oncology, Stanford University School of Medicine
2011~2016: Assistant Professor
2016~Current: Associate Professor
1. Song C, Hong BJ, Bok S, Lee CJ, Kim YE, Jeon SR, Wu HG, Lee YS, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn GO. (2016) Real-time tumor oxygenation changes after single high-dose radiation therapy in orthotopic and subcutaneous lung cancer in mice: clinical implication for stereotactic ablative body radiation therapy schedule optimization. Int J Radiat Oncol Biol Phys 95, 1022-1031
2. Ahn, G.O., Seita, J., Hong, B.J., Kim, Y.E., Bok, S., Lee, C.J., Kim, K.S., Lee, J.C., Leeper, N.J., Cooke, J.P., Kim, H.J., Kim, I.H., Weissman, I.L., Brown, J.M. (2014) Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8. Proc. Natl. Acad. Sci. U.S.A. 111, 2698-2703
3. Ahn, G.O., Tseng, D. Liao, C.H., Dorie, M.J., Czechowicz, A., and Brown, J.M. (2010) Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc. Natl. Acad. Sci. U.S.A. 107, 8363-8368 Highlighted in: Qualls J.E. and Murray P.J. (2010) A double agent in cancer: Stopping macrophages wounds tumors. Nat. Med. 16, 863-864
4. Ahn, G.O., and Brown, J.M. (2008) Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell, 13, 193-205
| Research Areas |
Radiation and Cancer Biology
• Role of HIF-1 myeloid cells affecting tumor response to radiotherapy and chemotherapy
• Investigation of mechanisms for tumor recurrence after radiotherapy
• Role of HIF-1 in myeloid cells in establishing pre-metastatic niche for tumor metastasis
• Developing strategies for overcoming normal tissue damage (including lung fibrosis, brain damage, esophagitis) induced by radiotherapy
Mouse models of human inflammatory diseases
• Cancer (various orthotopic models such as brain tumors, lung tumors, various metastasis models)
• Inflammation-associated cancer models
• Spontaneous cancer models (colon and liver cancers)
• Stroke (middle cerebral artery ligation through microsurgery)
• Hindlimb ischemia (femoral artery ligation through microsurgery)
• Hepatosteatosis
• Obesity and parabiosis
• Window chamber models (dorsal window and intracranial window chamber techniques) for real-time in vivo imaging