임신혁 교수 Profile

  • 경력
  • 논문
  • 연구분야
| Education |
B.S., Korea University, Seoul, Korea (1987)
M.S., Korea University, Seoul, Korea (1989)
Ph.D., Weizmann Institute of Science, Israel (2001)

| Career |
1991~1996: Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea.
2001~2003: Postdoctoral Fellow, Department of Pathology, Harvard Medical School
2004~2008: Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2008~2012: Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2012~2013: Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2014~Present: Professor, Division of Integrative Biosciences and Biotechnology, POSTECH
1. Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice. Sci Rep. 2016 Dec 15;6:39026.
2. Toll-like receptor 5 ligand flagellin-based immunomodulatory therapy for allergic asthma. J Allergy Clin Immunol 2016 Feb;137(2):426-35
3. NFAT1 controls contact hypersensitivity through regulation of activation induced cell death. Sci Rep. 2016 Jan 18;6:19453.
4. NFAT1 and JunB cooperatively regulate the IL-31 gene expression in CD4+ T cells in health and disease. J Immunol, 2015: 194(4): 1963-1974
5. 6-Methoxyflavone suppresses T cell activation by inhibiting NFAT1 translocation into the nucleus. J Immunol, 2014;193(6):2772-83.
6. Hif-2 is s an essential catabolic regulator of inflammatory rheumatoid arthritis Plos Biology. 2014: 12(6)21001881.
7. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013 Jan 16;146(3):217-227.
8. NFAT1 induced permissive chromatin modification facilitates NFκB mediated IL-9 transactivation. J Biol Chem. 2012;287(19):15445-57.
9. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 2012;188(5):2244-253
10. Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression. J Immunol. 2011;186(7):4098-109
11. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders; Proc Natl Acad Sci U S A. 2010 ;107(5):2159-64
12. Lef1 regulates transcription through gene looping. J Immunol 2009;183(8):5129-37
| Research Area |
1. Immune regulation and tolerance at the cellular and molecular level:
- Role of Ets1 transcription factor in the biogenesis of Treg cells, TFH cells and plasticity of Treg cells in autoimmunity and inflammatory disorders
2. Molecular mechanism of IL-10 gene regulation in CD4 T cells:
- Crosstalk between cis- and trans- acting factors
3. Role of gut microbiota in the development of immune system and elucidation of underling mechanism of action using a germ free mouse system.
4. Molecular mechanism of Treg cell generation induced by rationally selected probiotic bacteria: Identification of effector molecules and elucidation of underlying mechanism of action