김유미 Profile

  • 경력
  • 논문
  • 연구분야
| Education |
B.S., Seoul National University, Seoul, Korea (1992)
M.S., Seoul National University, Seoul, Korea (1994)
Ph.D., Thomas Jefferson University, Philadelphia, USA (2003)

| Career |
1994~1995: Researcher, Korean Ministry of Environment
2002~2007: Postdoctoral Fellow, Harvard Medical School and Whitehead Institute for Biomedical Research
2008~2009: Visiting Scholar, Whitehead Institute for Biomedical Research
2008~2009: Research Investigator, Novartis Institutes for Biomedical Research
2009~Present: Associate Professor, Department of Life Sciences, Pohang University of Science and Technology
1. Hong CP, Park A, Yang BG, Yun CH, Kwak MJ, et al. (2017) Gut-specific delivery of Th17 cells alleviates obesity and insulin resistance in mice. Gastroenterology (in press)
2. Sheng R, Jung DJ, Silkov A, Kim H, Singaram I, et al. (2016) Lipids regulate Lck protein activity through their interaction with the Lck Src homology domain. J Biol Chem 291, 17639
3. Park MJ, Sheng R, Silkov A, Jung DJ, Wang ZG, et al. (2016) SH domains serve as lipid binding modules for pTyr-signaling proteins. Mol Cell 62, 7
4. Hong CP, Yun CH, Lee GW, Park A, Kim YM, Jang MH (2015) TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders. Obesity 23, 2199
5. Huh JW, Shibata T, Hwang M, Kwon EH, Jang MS, et al. (2014) UNC93B1 is essential for the plasma membrane localization and signaling of Tolllike receptor 5. Proc Natl Acad Sci USA 111, 7072
6. Kim J, Huh J, Hwang M, Kwon EH, Jung DJ, et al. (2013) Acidic amino acid residues in the juxta-membrane region of the nucleotide-sensing toll-like receptors are important for UNC93B1 binding and signaling. J Immunol 190, 5287
7. Kim YM, Brinkmann MM, Paquet ME, Ploegh HL (2008) UNC93B delivers intracellular nucleotide-sensing TLRs to endolysosomes. Nature 452, 234
8. Kim YM, Brinkmann MM, Ploegh HL (2007) TLRs bent into shape. Nat Immunol 8, 675-7
9. Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM (2007) The interaction between the ER membrane protein UNC93B and TLRs 3,7, and 9 is crucial for TLR signaling. J Cell Biol 177, 265
10. Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL (2006) Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proc Natl Acad Sci USA 103, 3327
| Research Areas |
Regulatory mechanisms of innate immune receptor signaling
Immune receptor trafficking
Antigen receptor activation pathway
Pathogenesis of lupus
Regulation of interferon signaling