신근유 Profile

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Education, Training and Positions
2016~Current: Assistant Professor, Department of Life Sciences, Pohang University of Science and Technology
2014~2016: Assistant Professor, Department of Cell, Developmental & Cancer Biology, Department of Urology, Oregon Health & Science University School of Medicine, Portland, OR USA
2014~2016: Member, OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR USA
2014~2016: Member, Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA
2012~2014: Instructor, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA USA
2008~2012: Research Associate, Howard Hughes Medical Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA USA
2007~2008: Postdoctoral fellow, Department of Otolaryngology, Stanford University School of Medicine, Stanford, CA USA
2006~2007: Postdoctoral fellow, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA USA
2001~2006: Ph.D., Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI USA
1. Zhao C, Cai S, Shin K, Lim A, Kalisky T, Lu WJ, Clarke MF, Beachy PA. Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells. Science. 2017 Mar 9; Epub

2. Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, Clarke MF, Beachy PA. Control of inflammation by stromal Hedgehog pathway activation restrains colitis. PNAS. 2016 Nov 22; 113(47):E7545-E7553.

3. Lim, A, Shin K, Zhao, C, Kawano, C, Beachy PA. Spatially restricted Hedgehog signaling regulates HGF-induced branching of the adult prostate. Nat Cell Biol. 2014 Dec;16(12):1135-45.

4. Shin K, Lim A, Zhao C, Sahoo D, Pan Y, Spiekerkoetter E, Liao JC, Beachy PA. Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors. Cancer Cell. 2014 Oct 13;26(4):521-33.

5. Shin K, Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA. Cellular Origin of Bladder Neoplasia and Tissue Dynamics of its Progression to Invasive Carcinoma. Nat. Cell Biol. 2014 May;16(5):469-78. Highlighted in Nat. Rev. Cancer. 2014 Jun;14(6):386-7. Highlighted in Nat. Rev. Urol. 2014 Jun;11(6):302.

6. Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA. Hedgehog/Wnt Feedback Supports Regenerative Proliferation of Bladder Stem Cell. Nature. 2011 Apr 7;472(7341):110-4. Recommended by Faculty of 1000.

7. Oshima K, Shin K, Peng AW, Ricci AJ, Heller S. Mechanosensitive Hair Cell-Like Cells from Embryonic and Induced Pluripotent Stem Cells. Cell. 2010 May 14;141(4):704-16.
Our laboratory currently focuses on three major areas:
1) Stem cell interaction with its microenvironment during tissue regeneration, cancer progression, and metastasis,
with a particular emphasis on the Hedgehog signaling pathway (and other developmental pathways),
2) Novel strategy for regenerative medicine with a focus on in vivo tissue reprogramming and genome engineering, and
3) Personalized medicine to develop precise therapeutic intervention for individual cancer patients
with genetic variability using 3-dimensional in vitro cancer model.
To this end, we uses various in vitro/in vivo approaches including mouse genetics and stem cell organoid culture.