Human Embryonic Stem Cell
Cell replacement therapy is a promising strategy to cure many human diseases including degenerative ones. Discovery of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has made the patient-specific cell therapy possible. hESCs and iPSCs provide unlimited source of cells that can be differentiated into any cells of interest. Many research groups are actively working on using these cells for therapeutic purposes, but it is challenging to develop consistent and efficient therapy without thorough understanding of basic mechanisms of stem cell differentiation.
Our lab is focusing on molecular and cellular mechanisms through which hESCs and iPSCs generate all types of cells in our body. Furthermore, fundamental principles we discovered will be exploited to develop new techniques for therapeutic applications of hESCs and iPSCs.