Lab. of Molecular and Cellular Signaling
Although N-Terminal acetylation is an abundant and wide-spread protein modification in eukaryotes, very little is known about why most cellular proteins are be N-terminally acetylated over the past 60 years. We discovered that N-terminal acetylation creates specific protein degradation signals for a new branch of the N-end rule pathway, termed the Ac/N-end rule pathway (Hwang CS et al, Science, 2010), thus contributing to its roles in protein quality and subunit stoichiometry control (Shemorry A et al, Mol Cell, 2013; Kim HK et al, Cell, 2014) and blood pressure regulation via G-protein signaling (Park SE et al, Science, 2015). The Ac/N-end rule pathway is still beginning of the entirely new and broad research fields, We will more rigorously elucidate molecular mechanism and physiological functions of the novel proteolytic system under healthy or pathological conditions.